Is It Time to Change Course on Covid? | William Eden


What are we getting wrong with Covid, and what does it mean to adapt to it becoming an endemic disease? William Eden is a biotech and healthcare investor who has been paying close attention to the progress of the pandemic from many different angles. He recently posted a viral Twitter thread on the topic:

In this conversation with Rebel Wisdom's David Fuller they cover how the pandemic became politicised, how the authorities have been slow to adapt, and how the mandates are likely to backfire.

Here's the tweet thread:

I figure it’s worth posting a summary thread about my current thoughts on COVID to refer back to: Like many great blunders in history, we went into this without an exit plan. The landscape has changed such that risk is now individual cost/benefit more than public health. 

I was fully on board with early COVID Zero attempts. Containing and eliminating this virus, like we did with SARS1, would have been an enormous boon to the world. But the extremely anemic response in the entire world outside of Asia and Oceania guaranteed failure.

The fallback plan was red/green zones with local containment, lots of quarantine when moving between them, contact tracing, etc. De facto we got a few jurisdictions with this system, but I hoped it could work in many more countries. But that ship has also sailed now. 

The pandemic has now become endemic. The authorities seem to not have acknowledged this fact, despite it being blatantly evident. Doing so changes the optimal policy. This is where the lack of exit strategy is getting ugly… 

One potential exit path was vaccines. The initial efficacy was way better than I hoped! It seemed like maybe there was a promise (implicit or explicit) that getting mass adoption would stop the pandemic and/or return things to normal 

Unfortunately the biology of COVID is such that it’s like their distant cousins, the four endemic human coronaviruses that circulate and cause seasonal common colds. Immunity fades and you can catch each one annually. This is the future of COVID, forever. Face it. 

On the flip side: it sure looks like immunity (from vaccines or infections) confers a very significant protection against *very severe* COVID outcomes, long after it stops preventing infections and transmission. This is a great thing! And changes the risk calculus. 

The original justification for mass vaccination was that you could halt COVID spread, including to the people who couldn’t receive a vaccine. This makes some sense as a basis for policy! But it turned out to be false. 

If you get vaccinated, you are protecting *yourself* from the worst of COVID, but you aren’t protecting others for more than a few months. This makes it an *individual* decision, and NOT in the domain of public health policy. 

Similarly, masks do seem to offer some protection to both the wearer and others around them - but we can already individually choose to wear masks (including P100s or Versaflows or other measures) and get vaccinated. Anyone who wishes can protect themselves from COVID. 

The current policy seems to recognize *only benefits and not costs* of public health interventions. But there’s both direct costs, and costs to the fabric of society. Everyone knows our civilization is in a fragile state. We must not tear ourselves apart. 

Take vaccine mandates for example. They will likely succeed in pressuring people against their will to raise vaccination rates a few %. At the cost of **politicizing vaccines forever** and creating an unemployable undercaste of society. Surely they didn’t run the calculation. 

There are conceivably situations where this is warranted - a disease which doesn’t mutate rapidly, has severe illness, and immunity is lifelong. And in some cases it could be worth non-pharmaceutical interventions to slow the spread while deploying a vaccine! 

Furthermore, risk is reduced even more by the emergence of effective treatment options, from repurposed drugs easier on to Paxlovid today. With COVID becoming endemic and seasonal we need to deploy these - and continue working on even better options. 

At this point, COVID is over when we decide it’s over. And there’s no justification for continuing emergency measures and heavy handed policy when the risks have become manageable, and almost entirely individual, when it is literally tearing apart our society. 

If I were named COVID czar tomorrow:
-all pandemic restrictions and mandates ended immediately
-an impassioned plea to consider vaccination
-redirect resources to scaling therapeutics and developing better drugs and vaccines
-take any measures you need to protect yourself 

- William Eden

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